Interaction checker → Vitamin B12 + Metformin

Works well together

Can you take Vitamin B12 with metformin?

Metformin depletes B12

What happens

Long-term metformin reduces B12 absorption in the ileum; deficiency is common and often missed.

Drugs in this class include Metformin / Glucophage.

What to do about it

Supplementing B12 here is a good idea, not a risk. Ask for a B12 level.

This is general information compiled from published pharmacology, not advice about your situation. Your dose, your other medication and your bloodwork all matter, and a pharmacist can see those in a way this page cannot.

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