Interaction checker → St. John's Wort + SAM-e
Worth knowing aboutCan you take St. John's Wort and SAM-e together?
Additive serotonergic effect
What happens
Both raise serotonergic tone through different routes.
What to do about it
Worth discussing with the clinician managing your mood treatment before combining.
This is general information compiled from published pharmacology, not
advice about your situation. Your dose, your other medication and your bloodwork all matter,
and a pharmacist can see those in a way this page cannot.
Check your whole stack at once
Stackwise checks every pair in what you take, against your medication list, and moves things in your schedule when two of them need spacing apart.
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