Interaction checker → 5-HTP + St. John's Wort
Serious — worth a conversationCan you take 5-HTP and St. John's Wort together?
Serotonin syndrome risk
What happens
5-HTP raises serotonin production while St. John's Wort inhibits its reuptake.
What to do about it
This pairing has caused documented serotonin syndrome. There is no routine version of this combination — it is one to raise with a clinician before taking both.
This is general information compiled from published pharmacology, not
advice about your situation. Your dose, your other medication and your bloodwork all matter,
and a pharmacist can see those in a way this page cannot.
Check your whole stack at once
Stackwise checks every pair in what you take, against your medication list, and moves things in your schedule when two of them need spacing apart.
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