Interaction checker → Caffeine + Melatonin
Worth knowing aboutCan you take Caffeine and Melatonin together?
Caffeine cancels your melatonin
What happens
Caffeine has a ~5 hour half-life and blocks adenosine, directly opposing the sleep-onset signal you are paying melatonin to produce.
How far apart?
Leaving at least 8 hours between them avoids most of the effect.
What to do about it
Move all caffeine before 2pm, or the melatonin is wasted money.
This is general information compiled from published pharmacology, not
advice about your situation. Your dose, your other medication and your bloodwork all matter,
and a pharmacist can see those in a way this page cannot.
Check your whole stack at once
Stackwise checks every pair in what you take, against your medication list, and moves things in your schedule when two of them need spacing apart.
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